| Stage 4: Porto Recanati to Civitanova Marche, 166 km |
| 1. Alessandro Petacchi (Ita) Team Milram | 3:59:58 |
| 2. Oscar Freire (Esp) Rabobank |
| 3 .Filippo Pozzato (Ita) Liquigas |
| 4. Gerald Ciolek (Ger) Team High Road |
| 5. Jose Joaquin Rojas Gil (Esp) Caisse d'Epargne |
| 6. Daniele Pietropolli (Ita) LPR Brakes |
| 7. Enrico Gasparotto (Ita) Barloworld |
| 8. Ariel Maximiliano Richeze (Arg) CSF Group Navigare |
| 9. Heinrich Haussler (Ger) Gerolsteiner |
| 10. Tom Boonen (Bel) Quick Step |
|
| 30. Ryder Hesjedal (Can) Slipstream Chipotle p/b H30 | all s.t. |
|
| GC |
| 1. Niklas Axelsson (Swe) Serramenti PVC Diquigiovanni-Androni Giocattoli | 17:56:12 |
| 2. Enrico Gasparotto (Ita) Barloworld | at 0:10 |
| 3. Joaquim Rodriguez (Esp) Caisse d'Epargne | 0:18 |
| 4. Linus Gerdemann (Ger) Team High Road | 0:24 |
| 5. Danilo Di Luca (Ita) LPR Brakes | 0:32 |
| 6. Thomas Lovkvist (Swe) Team High Road | 0:40 |
| 7. Markus Fothen (Ger) Gerolsteiner | 0:50 |
| 8. Emanuele Sella (Ita) CSF Group Navigare | 0:54 |
| 9. Fabian Cancellara (Sui) Team CSC |
| 10. Tadej Valjavec (Slo) AG2r - La Mondiale | both s.t. |
|
| 13. Ryder Hesjedal (Can) Slipstream Chipotle p/b H30 | 1:05 |
