| Stage 4: Pizzo Calabro to Catanzaro-Lungomare, 183km |
| 1. Mark Cavendish (GBr) High Road | 4:49:09 |
| 2. Robert Förster (Ger) Gerolsteiner |
| 3. Daniele Bennati (Ita) Liquigas |
| 4. Assan Bazayev (Kaz) Astana |
| 5. Mirco Lorenzetto (Ita) Lampre |
| 6. Erik Zabel (Ger) Team Milram |
| 7. Robbie McEwen (Aus) Silence-Lotto |
| 8. Tony Martin (Ger) Team High Road |
| 9. Paolo Bettini (Ita) Quick Step |
| 10. Koldo Fernandez De Larrea (Esp) Euskaltel - Euskadi |
|
| 41. Christian Vande Velde (USA) Slipstream Chipotle p/b H30 |
| 67. Ryder Hesjedal (Can) Slipstream Chipotle p/b H30 |
| 85. Levi Leipheimer (USA) Astana | all s.t. |
| 153. Jason McCartney (USA) Team CSC | 6:39 |
| 178. Jonathan Patrick Mc Carty (USA) Slipstream Chipotle p/b H30 | 10:18 |
| 179. Danny Pate (USA) Slipstream Chipotle p/b H30 | s.t. |
|
| GC |
| 1. Franco Pellizotti (Ita) Liquigas | 16:41:26 |
| 2. Christian Vande Velde (USA) Slipstream Chipotle p/b H30 | at 0:01 |
| 3. Danilo Di Luca (Ita) LPR Brakes | 0.07 |
| 4. Morris Possoni (Ita) Team High Road | 0.08 |
| 5. Vincenzo Nibali (Ita) Liquigas | s.t. |
| 6. Nicki Sorensen (Den) Team CSC | 0.17 |
| 7. Kanstantsin Siutsou (Blr) Team High Road | 0.18 |
| 8. Paolo Savoldelli (Ita) LPR Brakes | 0.19 |
| 9. Andrea Noe (Ita) Liquigas | 0.22 |
| 10. Francesco Bellotti (Ita) Barloworld | 0.24 |
|
| 23. Levi Leipheimer (USA) Astana | 0:40 |
| 85. Ryder Hesjedal (Can) Slipstream Chipotle p/b H30 | 2:45 |
| 165. Jason McCartney (USA) Team CSC | 19:53 |
| 178. Danny Pate (USA) Slipstream Chipotle p/b H30 | 24:58 |
| 190. Jonathan Patrick Mc Carty (USA) Slipstream Chipotle p/b H30 | 31:51 |
